The most tragic of all these studies is 1) they exist. 2) we pay for them.
We do not need scientists to tell us what it is obvious, we cannot change our biological print, we can try but the result will be always Frankesteinish, not that there are scientists that still try to change our genome or at the end our existence as we know it.
Transgenderism is in the mind, it is all in the mind and not chemicals will fix it but therapy.
This is a terrific post and I’ve shared it. Thank you for all the sources at the end. I was curious about the statement you made about long term estrogen being harmful for females so I went to your primary source on that, the USPSTF recommendation. You cited the 2017 bulletin, but there’s an updated recommendation in 2022. What the recommendation concludes is that there is NO NET BENEFIT for hormone replacement therapy in post menopausal women for the purpose of preventing chronic conditions, such as stroke, heart, disease, diabetes, etc. That is, women who have already gone through menopause starting HRT in order to prevent chronic conditions will not get a net benefit. They say no net benefit because the HRT may be preventative in some cases (less fractures, less heart disease) but may cause higher risk of other conditions (stroke, thrombosis). The study explicitly excludes women who are taking HRT for management of menopausal symptoms. “USPSTF concludes that overall, both estrogen plus progestin and estrogen alone have no net benefit for the primary prevention of chronic conditions.”
Then there's the thing that is the idea of 'gender identity' which can know things it cannot know (the experience of growing up and living as the opposite sex) is not at all plausible. The first step is missing. Kids are being taught this though, being told they can be born in the wrong body, an impossible thing. It's pretty clear too in how boys and men (or vice versa) seem to have even less knowledge of girls and women's lives and seek to suppress women even being mentioned let alone having a say about their needs. If you press them on this, it's all stereotypes all the way down.
All else after that is just risk, there's no benefit. And it's only causing harm.
For me, one of the biggest dangers to puberty blockers/wrong sex hormones is the fact that it leaves these young people with permanently immature brains: https://lucyleader.substack.com/p/time-critical-brain-development Those who have been affected by this treatment will gain a year every birthday but will never have the expected critical thinking that usually goes along with them.
Hi, thanks for re-posting this excellent article. I too am a scientist, and also did a deep dive into the ‘literature’ when our son declared himself trans. I was similarly aghast at the complete lack of any credible studies or evidence for the benefits or efficacy of transition, and generally at the extremely poor quality of ‘research’ in the US. (of course this somehow made no difference to my otherwise intelligent son).
I wonder if there is an update that includes work since this column was published?
Thank you for this. My son has been on wrong-sex hormones for 10 years. Any of the many pleas I’ve made to him to stop have been reduced by him as my feelings. And my feelings don’t trump his feelings. He identifies as a woman, and that’s that.
But this is more than that. It’s a cult, a contagion, a religious ideology that sweeps young people into its darkness and erases family connections.
Having this science - as you’ve presented it - finally gives me armor. I can speak to the dangers he’s doing to himself, without emotion. These are not feelings, they’re facts. Indisputable and true. We have to shout them out, again and again, to be heard and stop this madness.
Deep gratitude to the author for the quality of all parts of this body of work: observations, research, references, presentation, and conclusions. Truth is still truth, even if one does not believe it.
I encourage Author to do a parallel deep dive on the topic of natal females taking testosterone. Your excellent presentation of facts is needed and appreciated.
Iran has been at the forefront of pushing transition on their homosexual population for years, since homosexuality there is punishable by death.
This BBC article from 2014 on gay Iranian refugees contrasts starkly with their reporting on trans issues today. It actually accurately reports on regret and fear rather than just euphoria and satisfaction.
How were western media and medicine captured so completely?
This is one of the most thorougly researched pieces I've seen on this topic. The point about ventricular enlargement being a marker for Alzheimer's risk is honestly terrifying and I dunno why more doctors aren't discussing it openly. I spent months trying to find this kind of data when a close friend's kid got caught up in this, and its wild how buried these studies are.
I suggest the author had access to university libraries that can pay the exorbitant prices journals ask for access . A huge barrier to those who are academically literate but outside those elite institutions.
As a mother (and non-scientist) who had a daughter disappear down the harmful trans rabbit hole while in college, one of the most striking things about this phenomenon is the widespread belief that it could even remotely be true. It is easily recognizable to many that it is a bunch of hooey. They say that scientists are most likely to believe in scientific theories. "If all you have is a hammer, everything looks like a nail," as the saying goes. Science is oft driven by the greed and power of those it serves.
I do not believe my daughter ever had 'gender dysphoria.' I believe her desire to 'be trans' was groomed - and then affirmed- on her college campus. It is a mind game requiring believers to dissociative from their reality including from her relatives who never believed. (adding : she is no longer 'trans.')
That being said thanks for putting these important resources together. I hope in the years since your son has woken up or soon will.
My son (all three of our precious adult kids removed themselves from our lives about 3 years ago) sent me the following I put in quotations a couple days ago.... would you want to share with me, here or in private, on the topic my son would " probably be interested in hearing"? 🩷 Hugs from one mama to another
"So my only wish for you and dad remains that you both constantly pursue knowledge and growth for you individually and from other parents of not-straight children who have either had to learn to make peace with the consequences of their parenting choices, or have somehow been able to find a new common ground with their adult kids, based on mutual trust and commitment to acknowledging where we each are on our healing journey. If you ever find any of the latter, I'd probably be interested in hearing how they are navigating it because the real life examples of that happening I've found are almost nonexistent."
Great article. Unfortunately nothing will change until the Dr and endocrinologists start to tell the truth. My son says if the endocrinologist at the Mayo Clinic says the hormones are safe then they must be safe. How do we get these so called Dr to stop?
I believe that God is going to put an end to this.....it is WAY bigger than any person or large group of people or organization. Children's Health Defense is suing the AAP right now...but to think that we could ever litigate or legislate our way through this horrific situation is just not based in reality. It's too much.....so something huge....something biblical.....has to take place and I am of the belief that it is coming in the not too distant future.
Sadly most medical clinics/organizations are preying on all kinds of people, and they use in many instances well meaning intelligent people to do it. I imagine most doctors and nurses get into medicine with good intentions....they have no idea that they are going to be brainwashed into believing that what they are taught is how it is supposed to be! The world is in for a huge change. Most jobs out there are pushing the enemy's agenda to steal, kill, and destroy. Think about even all the young kids they have working in fast food restaurants and grocery stores assisting in the sale of all kinds of junk "food" (I wouldn't even call some of it food). Maybe I'm a little over the top but if you start looking into things you can't unlearn what you learn! The picture is huge and big things are on the horizon!
I would like to know how this father's child is doing now, since this is a repost.
Sadly, our media just publishes whatever deftly-spun taglines or snippets from studies activists give them that appear to make these treatments appear safe and effective. And the journalists who try to present alternatives, like Singal, Ben Ryan, Showalter, etc. are lambasted. The science is bad, but the media exacerbates the problem by amplifying it and making it part of the common discourse, like the suicide myth.
I asked a cardiologist "Do you have any concerns about a young woman (my daughter) taking testosterone?". Her answer: "Don't worry and don't spend too much time on the internet". I asked a gynaecologist. Her answer: " Don't worry, it's just a phase and it's all reversible." I asked an endicronologist and he refused to answer.
Have you read the April 2024 Cass Review - a 388pp report prepared by Professor Hilary Cass for the UK's NHS which examined and weighed ALL the published literature and took 4 years to prepare? See https://webarchive.nationalarchives.gov.uk/ukgwa/20250310144409mp_/https://cass.independent-review.uk/wp-content/uploads/2024/04/CassReview_Final.pdf Prof Cass is a paediatrician and past-President of the Royal College of Paediatrics in the UK. She recommended that children should ONLY be given puberty blockers as part of a proper medical trial to evaluate efficacy. This limited use was viewed as a sop to the "gender" zealots in the NHS. Everyone thought that the NHS Ethics in Research committee would fail such a trial. However they didn't! The recently approved "PATHWAYS" trial has provoked an outcry: 130K signatures on a petition begging the Secretary of State for Health, Wes Streeting, to stop it on ethical grounds and separate letters from many leading clinicians in other fields in the UK to him. The final decision rests with the Secretary of State for Health, Wes Streeting.
Wait until the lawsuits with huge payouts come; this'll all fall like a house of cards, even if none of US live long enough to see it.
The most tragic of all these studies is 1) they exist. 2) we pay for them.
We do not need scientists to tell us what it is obvious, we cannot change our biological print, we can try but the result will be always Frankesteinish, not that there are scientists that still try to change our genome or at the end our existence as we know it.
Transgenderism is in the mind, it is all in the mind and not chemicals will fix it but therapy.
This is a terrific post and I’ve shared it. Thank you for all the sources at the end. I was curious about the statement you made about long term estrogen being harmful for females so I went to your primary source on that, the USPSTF recommendation. You cited the 2017 bulletin, but there’s an updated recommendation in 2022. What the recommendation concludes is that there is NO NET BENEFIT for hormone replacement therapy in post menopausal women for the purpose of preventing chronic conditions, such as stroke, heart, disease, diabetes, etc. That is, women who have already gone through menopause starting HRT in order to prevent chronic conditions will not get a net benefit. They say no net benefit because the HRT may be preventative in some cases (less fractures, less heart disease) but may cause higher risk of other conditions (stroke, thrombosis). The study explicitly excludes women who are taking HRT for management of menopausal symptoms. “USPSTF concludes that overall, both estrogen plus progestin and estrogen alone have no net benefit for the primary prevention of chronic conditions.”
https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/menopausal-hormone-therapy-preventive-medication
Then there's the thing that is the idea of 'gender identity' which can know things it cannot know (the experience of growing up and living as the opposite sex) is not at all plausible. The first step is missing. Kids are being taught this though, being told they can be born in the wrong body, an impossible thing. It's pretty clear too in how boys and men (or vice versa) seem to have even less knowledge of girls and women's lives and seek to suppress women even being mentioned let alone having a say about their needs. If you press them on this, it's all stereotypes all the way down.
All else after that is just risk, there's no benefit. And it's only causing harm.
For me, one of the biggest dangers to puberty blockers/wrong sex hormones is the fact that it leaves these young people with permanently immature brains: https://lucyleader.substack.com/p/time-critical-brain-development Those who have been affected by this treatment will gain a year every birthday but will never have the expected critical thinking that usually goes along with them.
Additionally, there is no way that a child can give informed consent about becoming permanently sterilized and removing the possibility of a pleasurable sex life as an adult: https://lucyleader.substack.com/p/removing-the-possibility-of-normal
And I don't believe that parents have the right to remove the possibility of normal from their children.
Hi, thanks for re-posting this excellent article. I too am a scientist, and also did a deep dive into the ‘literature’ when our son declared himself trans. I was similarly aghast at the complete lack of any credible studies or evidence for the benefits or efficacy of transition, and generally at the extremely poor quality of ‘research’ in the US. (of course this somehow made no difference to my otherwise intelligent son).
I wonder if there is an update that includes work since this column was published?
Thank you for this. My son has been on wrong-sex hormones for 10 years. Any of the many pleas I’ve made to him to stop have been reduced by him as my feelings. And my feelings don’t trump his feelings. He identifies as a woman, and that’s that.
But this is more than that. It’s a cult, a contagion, a religious ideology that sweeps young people into its darkness and erases family connections.
Having this science - as you’ve presented it - finally gives me armor. I can speak to the dangers he’s doing to himself, without emotion. These are not feelings, they’re facts. Indisputable and true. We have to shout them out, again and again, to be heard and stop this madness.
Thank you.
Believe the Science!
Believe the Science is whatever most conveniently justifies my ideology!
Deep gratitude to the author for the quality of all parts of this body of work: observations, research, references, presentation, and conclusions. Truth is still truth, even if one does not believe it.
I encourage Author to do a parallel deep dive on the topic of natal females taking testosterone. Your excellent presentation of facts is needed and appreciated.
Iran has been at the forefront of pushing transition on their homosexual population for years, since homosexuality there is punishable by death.
This BBC article from 2014 on gay Iranian refugees contrasts starkly with their reporting on trans issues today. It actually accurately reports on regret and fear rather than just euphoria and satisfaction.
How were western media and medicine captured so completely?
https://www.bbc.com/news/magazine-29832690
This is one of the most thorougly researched pieces I've seen on this topic. The point about ventricular enlargement being a marker for Alzheimer's risk is honestly terrifying and I dunno why more doctors aren't discussing it openly. I spent months trying to find this kind of data when a close friend's kid got caught up in this, and its wild how buried these studies are.
I suggest the author had access to university libraries that can pay the exorbitant prices journals ask for access . A huge barrier to those who are academically literate but outside those elite institutions.
As a mother (and non-scientist) who had a daughter disappear down the harmful trans rabbit hole while in college, one of the most striking things about this phenomenon is the widespread belief that it could even remotely be true. It is easily recognizable to many that it is a bunch of hooey. They say that scientists are most likely to believe in scientific theories. "If all you have is a hammer, everything looks like a nail," as the saying goes. Science is oft driven by the greed and power of those it serves.
I do not believe my daughter ever had 'gender dysphoria.' I believe her desire to 'be trans' was groomed - and then affirmed- on her college campus. It is a mind game requiring believers to dissociative from their reality including from her relatives who never believed. (adding : she is no longer 'trans.')
That being said thanks for putting these important resources together. I hope in the years since your son has woken up or soon will.
Mothers Grim - Have you see Mia Hughes talk about the 'monster upstream'?https://youtu.be/a8uBdSoQCKQ?si=LwpslosKt4oy7fBV
I'm so sorry for your heartache too. May I ask if you currently have any sort of connections with your daughter?
Yes!
Oh I'm so glad to hear that!!
My son (all three of our precious adult kids removed themselves from our lives about 3 years ago) sent me the following I put in quotations a couple days ago.... would you want to share with me, here or in private, on the topic my son would " probably be interested in hearing"? 🩷 Hugs from one mama to another
"So my only wish for you and dad remains that you both constantly pursue knowledge and growth for you individually and from other parents of not-straight children who have either had to learn to make peace with the consequences of their parenting choices, or have somehow been able to find a new common ground with their adult kids, based on mutual trust and commitment to acknowledging where we each are on our healing journey. If you ever find any of the latter, I'd probably be interested in hearing how they are navigating it because the real life examples of that happening I've found are almost nonexistent."
*If you want a little bit of more background, here's a snippet....https://open.substack.com/pub/rejoicinginhope/p/you-are-not-alone?utm_source=share&utm_medium=android&r=5pxpd5 (PITT parents with inconvenient truths about trans, posted an edited version of it)
Wow. All I can say to tis is wow and thanks!!!!
Great article. Unfortunately nothing will change until the Dr and endocrinologists start to tell the truth. My son says if the endocrinologist at the Mayo Clinic says the hormones are safe then they must be safe. How do we get these so called Dr to stop?
I believe that God is going to put an end to this.....it is WAY bigger than any person or large group of people or organization. Children's Health Defense is suing the AAP right now...but to think that we could ever litigate or legislate our way through this horrific situation is just not based in reality. It's too much.....so something huge....something biblical.....has to take place and I am of the belief that it is coming in the not too distant future.
The Mayo Clinic has been preying on the elderly and their families for decades in Florida. They practice medicare manipulation, not medicine.
Sadly most medical clinics/organizations are preying on all kinds of people, and they use in many instances well meaning intelligent people to do it. I imagine most doctors and nurses get into medicine with good intentions....they have no idea that they are going to be brainwashed into believing that what they are taught is how it is supposed to be! The world is in for a huge change. Most jobs out there are pushing the enemy's agenda to steal, kill, and destroy. Think about even all the young kids they have working in fast food restaurants and grocery stores assisting in the sale of all kinds of junk "food" (I wouldn't even call some of it food). Maybe I'm a little over the top but if you start looking into things you can't unlearn what you learn! The picture is huge and big things are on the horizon!
I would like to know how this father's child is doing now, since this is a repost.
Sadly, our media just publishes whatever deftly-spun taglines or snippets from studies activists give them that appear to make these treatments appear safe and effective. And the journalists who try to present alternatives, like Singal, Ben Ryan, Showalter, etc. are lambasted. The science is bad, but the media exacerbates the problem by amplifying it and making it part of the common discourse, like the suicide myth.
I asked a cardiologist "Do you have any concerns about a young woman (my daughter) taking testosterone?". Her answer: "Don't worry and don't spend too much time on the internet". I asked a gynaecologist. Her answer: " Don't worry, it's just a phase and it's all reversible." I asked an endicronologist and he refused to answer.
Wow. 😖
Hello
Have you read the April 2024 Cass Review - a 388pp report prepared by Professor Hilary Cass for the UK's NHS which examined and weighed ALL the published literature and took 4 years to prepare? See https://webarchive.nationalarchives.gov.uk/ukgwa/20250310144409mp_/https://cass.independent-review.uk/wp-content/uploads/2024/04/CassReview_Final.pdf Prof Cass is a paediatrician and past-President of the Royal College of Paediatrics in the UK. She recommended that children should ONLY be given puberty blockers as part of a proper medical trial to evaluate efficacy. This limited use was viewed as a sop to the "gender" zealots in the NHS. Everyone thought that the NHS Ethics in Research committee would fail such a trial. However they didn't! The recently approved "PATHWAYS" trial has provoked an outcry: 130K signatures on a petition begging the Secretary of State for Health, Wes Streeting, to stop it on ethical grounds and separate letters from many leading clinicians in other fields in the UK to him. The final decision rests with the Secretary of State for Health, Wes Streeting.
And the wider and more recent Nov 2025 American Health and Human Services report which excoriated the "GAC" field, calling out "sex-rejecting" procedures: https://www.hhs.gov/press-room/hhs-releases-peer-reviewed-report-discrediting-pediatric-sex-rejecting-procedures.html
Finally: https://www.hhs.gov/press-room/hhs-acts-bar-hospitals-performing-sex-rejecting-procedures-children.html
It is not science which will stop the "trans train" but an outcry from concerned parents, and the insurance companies getting cold feet.