"It means that, for reasons that researchers still cannot explain, the testicles don’t get the message from the brain to make enough Testosterone."
Is that that right? I have learned it is increasing LH that triggers the testes to atrophy, more. They start to atrophy in the womb. XXY boys have a mini-puberty just like most other boys, in infancy, starting a few weeks after birth and lasting up to 12 months. Then for roughly 10 years their testosterone is nominal, just like most other boys. From age 9 puberty can begin, I started at age 10 and their testes grow, yes they do. XXY boys get to Tanner stage 2-3 before they experience lessening effect.
What I do not know is why the seminiferous tubules hyalinise, become like glass, and that is what causes testicular atrophy, then hypogonadism.
I did subscribe, click on my profile image, images of me at various ages, and see my karyotype, am XXY, have been all my life <---- that's a joke. I was diagnosed on 23/11/1976 - the exact same day I got my driver licence, which was a struggle all of itself, almost everything I learned was a struggle. Occasionally I stumbled across something I had no problem learning. 3 of those things were Music, Pottery and Human Biology. I am male and nobody will convince me otherwise. I have met in person many XXY males, adults and children, and none has ever expressed an idea they were not male. Only on the internet do I see such ideas. Making me wonder; "are these people really XXY?"
Thank you, thank you, thank you! As the mother of a son with 48XXXY, I feel like you ran through my brain and so brilliantly put together all the thoughts I haven’t been able to get to paper. I will be sharing far and wide.
I've educated myself on Klinefelter's Syndrome ~ 30 years ago when I was referred to provide physical therapy to a patient who had it as a comorbidity (to the diagnosis for which I was providing physical therapy). Since then, I treated a few additional patients who also had Klinefelter's.
I was angry, but not shocked, when the "transgender cult" "claimed" people with this condition (as well as XXYY Syndrome, Turner's Syndrome, etc).
Thank you for writing this article. My best to you, your son and the rest of your family.
NPR is one of the primary providers of woke lies there is, broadcasting bias confirmation from leftist universities to millions of progressives. Pure "1984" radio.
Thank you for this educational article. It came at the right time. The anti science, anti women, anti Democratic, religious movement, has evolving talking points. They all repeat things from Google searches, as more scientific questions are posed. The latest is; that there are trans frogs and fish, intersex people etc. etc, and therefore their ideologies are real, yada yada yada, and I'm a, TERF, Nazi.. blah blah blah, you know, the usual BS. Personally, I don't think accepting the laws of nature are "radical," but maybe they actually are these days? Because you know, nature is a bigot. She is. She designed a perfect system of balance and harmony, that has worked for Millenia. We are constructs of her, regardless of belief. Many Trans women support the laws of nature, reality and science, while living their true authentic life. I support them, and admire their courage. It's just these radicals that are screaming the loudest. I'm sure this condition will be used soon in their talking points. And if you point out that it's a, genetic condition, you'll just be name- called and demonized for inserting reality into their magical- belief -system. Reality is tyranny to this extreme bunch.
Thank you for sharing your story and educating me and others. It's good to learn actual scientific information that dispels yet another reason it's normal to be "born in the wrong body."
This is interesting. In college I had a roommate with kleinfelfer. But she was a female, at least, that’s how she was living.
You could tell from looking at her that there was something off (very tall, gangly. Broad shoulders, wide jaw, etc), and she had behavioral/social issues too. I remember one day she revealed to us (it was an apartment style dorm with 4 girls) that she had a genetic condition called kleinfelter and that she had XXY chromosomes and penis but her parents raised her as a girl. She had breasts, so I don’t know if that’s a typical thing or not. One of the roommates was livid. The rest of us were compassionate but we didn’t really ask too much more about it and just tried to support her.
I didn’t realize this only affects males as that has been my only experience hearing of anyone with kleinfelter.
I am XXY, I wasn’t diagnosed until my late teens. This was several decades ago, and as a male I was offered Testosterone first by weekly injections, and much later by gel. I’ve led a fairly normal adult life, yes, my muscle tone has always been lacking , I’ve always been tall and gangly, brain function wise my attention levels leave much to be desired but I’m intelligent and I’ve learnt to work around my attention limitations without alerting anyone. I have a well paid job and I’m happily married.
In my 20’s I was a bit undecided about my gender and when the gel became available, I went abroad for several years, had all types of relationships and through trial and error, I discovered I was a straight guy attracted to females. I did need to find this out for myself and it was a personal journey so I hadn’t told anyone back home before or since about this episode in my life. Also this was decades before the current obsession with gender.
I follow this Stack because I wonder what would have happened had I been born later and been diagnosed in this current period. I was so vulnerable back then, no hormones throughout my teenage years, I went through puberty 6 years after everyone else. I’m sure mentally I would have been open to convincing sounding professionals and who knows what agendas would have been pushed on to me. I am grateful I was left alone to make my own decisions and find my own way through a very difficult period.
Hi, Inch - I'm also someone born with a condition affecting sexual development (intersex), presenting so that a chromosome test was immediately recommended and came back XY. Despite many surgeries and supplements, I didn't have a normal puberty, I sit to pee, and I remain sterile.
I certainly feel that I'm a different kind of male, after a personal journey that included being a father figure to more than a few kids, (including someone XXY who faces many of the challenges you face). I also was born to a time when a single agenda ruled: we can make him just like the other boys - my parents were convinced that fantasy was possible...
Intersex people most often identify over abnormal puberty, the difficulty of getting good medical care for the health of our bodies, and the lack of societal acceptance as [not the same kind of] M or F. Just as the hubris of the medical field convinced my parents (and still convinces many) to subject kids to genital 'conformance' surgeries as kids and pretend they're no different, the medical hubris now is psychological too.
We just need recognition to grow up unashamed of our bodies, not used as pawns or research subjects, or to win trans arguments on either side.
One way I think we can contribute to this topic is to remind folks that some of us were born to live literally on the margin of binary sex. Our presence is not a political threat, not a proof of a gender position, just a biological reality that should have social acceptance. Feel free to read my journal entries, a narrative exploration of the topic... sarisimpapers.substack.com
Your voice is critical in this conversation! Thank you for speaking out. I am quite familiar with XXY, as a loved one of mine is XXY. As you probably very well know, while there can be many developmental challenges, as described in the essay, the other side of the coin is that most guys with XXY lead pretty "normal" lives. (75% are undiagnosed in their lifetimes, so they go through their whole life not knowing about it). My loved one with XXY is also bright and intelligent.
I'm touched by your insights about how, considering your situation, you could have been vulnerable to having an agenda pushed on you. Thank you for speaking from your own experience.
"It means that, for reasons that researchers still cannot explain, the testicles don’t get the message from the brain to make enough Testosterone."
Is that that right? I have learned it is increasing LH that triggers the testes to atrophy, more. They start to atrophy in the womb. XXY boys have a mini-puberty just like most other boys, in infancy, starting a few weeks after birth and lasting up to 12 months. Then for roughly 10 years their testosterone is nominal, just like most other boys. From age 9 puberty can begin, I started at age 10 and their testes grow, yes they do. XXY boys get to Tanner stage 2-3 before they experience lessening effect.
What I do not know is why the seminiferous tubules hyalinise, become like glass, and that is what causes testicular atrophy, then hypogonadism.
I did subscribe, click on my profile image, images of me at various ages, and see my karyotype, am XXY, have been all my life <---- that's a joke. I was diagnosed on 23/11/1976 - the exact same day I got my driver licence, which was a struggle all of itself, almost everything I learned was a struggle. Occasionally I stumbled across something I had no problem learning. 3 of those things were Music, Pottery and Human Biology. I am male and nobody will convince me otherwise. I have met in person many XXY males, adults and children, and none has ever expressed an idea they were not male. Only on the internet do I see such ideas. Making me wonder; "are these people really XXY?"
Very well-written, with points clearly stated, explains clearly this rare occurrence with the effects in daily life & development
Thank you, thank you, thank you! As the mother of a son with 48XXXY, I feel like you ran through my brain and so brilliantly put together all the thoughts I haven’t been able to get to paper. I will be sharing far and wide.
Thank You!!
I appreciate this so much! Thank you.
Thank you for sharing this. I hate the fact the activists use conditions like your son’s to “prove” their ideology.
This is such a great article. thank you so much!
Thank you very much for that explanations. Best regards Brigitte. Ich wish you all the best ♥️
I've educated myself on Klinefelter's Syndrome ~ 30 years ago when I was referred to provide physical therapy to a patient who had it as a comorbidity (to the diagnosis for which I was providing physical therapy). Since then, I treated a few additional patients who also had Klinefelter's.
I was angry, but not shocked, when the "transgender cult" "claimed" people with this condition (as well as XXYY Syndrome, Turner's Syndrome, etc).
Thank you for writing this article. My best to you, your son and the rest of your family.
NPR is one of the primary providers of woke lies there is, broadcasting bias confirmation from leftist universities to millions of progressives. Pure "1984" radio.
Thank you for this educational article. It came at the right time. The anti science, anti women, anti Democratic, religious movement, has evolving talking points. They all repeat things from Google searches, as more scientific questions are posed. The latest is; that there are trans frogs and fish, intersex people etc. etc, and therefore their ideologies are real, yada yada yada, and I'm a, TERF, Nazi.. blah blah blah, you know, the usual BS. Personally, I don't think accepting the laws of nature are "radical," but maybe they actually are these days? Because you know, nature is a bigot. She is. She designed a perfect system of balance and harmony, that has worked for Millenia. We are constructs of her, regardless of belief. Many Trans women support the laws of nature, reality and science, while living their true authentic life. I support them, and admire their courage. It's just these radicals that are screaming the loudest. I'm sure this condition will be used soon in their talking points. And if you point out that it's a, genetic condition, you'll just be name- called and demonized for inserting reality into their magical- belief -system. Reality is tyranny to this extreme bunch.
Thank you for sharing your story and educating me and others. It's good to learn actual scientific information that dispels yet another reason it's normal to be "born in the wrong body."
This is interesting. In college I had a roommate with kleinfelfer. But she was a female, at least, that’s how she was living.
You could tell from looking at her that there was something off (very tall, gangly. Broad shoulders, wide jaw, etc), and she had behavioral/social issues too. I remember one day she revealed to us (it was an apartment style dorm with 4 girls) that she had a genetic condition called kleinfelter and that she had XXY chromosomes and penis but her parents raised her as a girl. She had breasts, so I don’t know if that’s a typical thing or not. One of the roommates was livid. The rest of us were compassionate but we didn’t really ask too much more about it and just tried to support her.
I didn’t realize this only affects males as that has been my only experience hearing of anyone with kleinfelter.
I am XXY, I wasn’t diagnosed until my late teens. This was several decades ago, and as a male I was offered Testosterone first by weekly injections, and much later by gel. I’ve led a fairly normal adult life, yes, my muscle tone has always been lacking , I’ve always been tall and gangly, brain function wise my attention levels leave much to be desired but I’m intelligent and I’ve learnt to work around my attention limitations without alerting anyone. I have a well paid job and I’m happily married.
In my 20’s I was a bit undecided about my gender and when the gel became available, I went abroad for several years, had all types of relationships and through trial and error, I discovered I was a straight guy attracted to females. I did need to find this out for myself and it was a personal journey so I hadn’t told anyone back home before or since about this episode in my life. Also this was decades before the current obsession with gender.
I follow this Stack because I wonder what would have happened had I been born later and been diagnosed in this current period. I was so vulnerable back then, no hormones throughout my teenage years, I went through puberty 6 years after everyone else. I’m sure mentally I would have been open to convincing sounding professionals and who knows what agendas would have been pushed on to me. I am grateful I was left alone to make my own decisions and find my own way through a very difficult period.
Hi, Inch - I'm also someone born with a condition affecting sexual development (intersex), presenting so that a chromosome test was immediately recommended and came back XY. Despite many surgeries and supplements, I didn't have a normal puberty, I sit to pee, and I remain sterile.
I certainly feel that I'm a different kind of male, after a personal journey that included being a father figure to more than a few kids, (including someone XXY who faces many of the challenges you face). I also was born to a time when a single agenda ruled: we can make him just like the other boys - my parents were convinced that fantasy was possible...
Intersex people most often identify over abnormal puberty, the difficulty of getting good medical care for the health of our bodies, and the lack of societal acceptance as [not the same kind of] M or F. Just as the hubris of the medical field convinced my parents (and still convinces many) to subject kids to genital 'conformance' surgeries as kids and pretend they're no different, the medical hubris now is psychological too.
We just need recognition to grow up unashamed of our bodies, not used as pawns or research subjects, or to win trans arguments on either side.
One way I think we can contribute to this topic is to remind folks that some of us were born to live literally on the margin of binary sex. Our presence is not a political threat, not a proof of a gender position, just a biological reality that should have social acceptance. Feel free to read my journal entries, a narrative exploration of the topic... sarisimpapers.substack.com
Your voice is critical in this conversation! Thank you for speaking out. I am quite familiar with XXY, as a loved one of mine is XXY. As you probably very well know, while there can be many developmental challenges, as described in the essay, the other side of the coin is that most guys with XXY lead pretty "normal" lives. (75% are undiagnosed in their lifetimes, so they go through their whole life not knowing about it). My loved one with XXY is also bright and intelligent.
I'm touched by your insights about how, considering your situation, you could have been vulnerable to having an agenda pushed on you. Thank you for speaking from your own experience.
Thank you x