Animal studies mentioned above on the effects of androgen deprivation should have raised concerns about similar effects of puberty blockers on the brains of natal boys. The added effect of oestrogen should have been considered because by 2006 it was described in medical literature.
Three studies have compared the effects of cross-sex hormones on the brain before and after treatment. One, in which oestrogen and an added anti-testosterone drug were given to transgendering males, found a reduction in brain “ten times the average annual decrease in healthy adults” after only four months. After a similar time, the brain volume increased in females receiving testosterone.
Other studies[58] confirm that shrinkage of male brains on oestrogen is associated with reduction in the size of grey matter after only six months. Increased size of grey matter in females on testosterone is associated with altered microstructure of neurons[59].
Oestrogen may reduce grey matter in males by inducing apoptosis, or death of neuronal and supporting cells. Testosterone may increase the size of female grey matter by an anabolic effect on molecular components of cells. As brains are chromosomally programmed before birth to respond to specific stimulation of appropriate sex hormones in puberty, there should be no surprise at disruption when the hormone they were expecting has been substituted by one they were not.
There may be other unexpected side effects in males taking estrogen. They appear to have an increased risk for MS, a very serious neurological condition.
Conclusions: We report a positive association (a near seven-fold elevation of rates) between GID and subsequent MS in males. Our findings support a postulated association between low testosterone and MS risk, and highlight a need for further exploration of the influence of feminizing sex hormones on MS risk.T
Can you unpack that and explain what that means in layman terms, and what also are the long term effects of it all?
Yes. I found this information on the site GenderHQ (and it's grey matter, not white matter, oops).
Here is a link to the study by John Whitehall (2017): https://quadrant.org.au/magazine/2017/05/childhood-gender-dysphoria-responsibility-courts/#_edn60
The information I was referring to:
Animal studies mentioned above on the effects of androgen deprivation should have raised concerns about similar effects of puberty blockers on the brains of natal boys. The added effect of oestrogen should have been considered because by 2006 it was described in medical literature.
Three studies have compared the effects of cross-sex hormones on the brain before and after treatment. One, in which oestrogen and an added anti-testosterone drug were given to transgendering males, found a reduction in brain “ten times the average annual decrease in healthy adults” after only four months. After a similar time, the brain volume increased in females receiving testosterone.
Other studies[58] confirm that shrinkage of male brains on oestrogen is associated with reduction in the size of grey matter after only six months. Increased size of grey matter in females on testosterone is associated with altered microstructure of neurons[59].
Oestrogen may reduce grey matter in males by inducing apoptosis, or death of neuronal and supporting cells. Testosterone may increase the size of female grey matter by an anabolic effect on molecular components of cells. As brains are chromosomally programmed before birth to respond to specific stimulation of appropriate sex hormones in puberty, there should be no surprise at disruption when the hormone they were expecting has been substituted by one they were not.
There may be other unexpected side effects in males taking estrogen. They appear to have an increased risk for MS, a very serious neurological condition.
Conclusions: We report a positive association (a near seven-fold elevation of rates) between GID and subsequent MS in males. Our findings support a postulated association between low testosterone and MS risk, and highlight a need for further exploration of the influence of feminizing sex hormones on MS risk.T
Wow thats some crazy 411 to learn, I only wonder why I've heard about it before from anti-tran advocates?
Must not be the most well spread bit of info or they'd be blaring it from every online bullhorn they have.
Maybe this will be helpful. https://mungeribabu.substack.com/p/estrogen-is-really-bad-for-men
Thank you!